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وبلاگ پزشکان طب سوزنی ایران - Metabonomic analysis reveals efficient ameliorating effects of acupoint stimulations on the menopause-caused alterations in mammalian metabolism.

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Metabonomic analysis reveals efficient ameliorating effects of acupoint stimulations on the menopause-caused alterations in mammalian metabolism.

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تاریخ:یکشنبه 18 اسفند 1392-07:12 ب.ظ




در بیمارن تحت درمان طب سوزنی تغییرات هورمونی بسیار خوبی دیده میشود که سبب بهتر کار کردن تخمدان ها و تاخیر یا کنترل علایم یائسگی میگردد.این مقاله بیانگر تاثیر طب سوزنی در بهبود کار تخمدانها میباشد.

2014 Jan 10;4:3641. doi: 10.1038/srep03641.

Zhang L1, Wang Y2, Xu Y3, Lei H1, Zhao Y1, Li H1, Lin X4, Chen G4, Tang H5.

Abstract

Acupoint stimulations are effective in ameliorating symptoms of menopause which is an unavoidable ageing consequence for women. To understand the mechanistic aspects of such treatments, we systematically analyzed the effects of acupoint laser-irradiation and catgut-embedding on the ovariectomy-induced rat metabolic changes using NMR and GC-FID/MS methods. Results showed that ovariectomization (OVX) caused comprehensive metabolic changes in lipid peroxidation, glycolysis, TCA cycle, choline and amino acid metabolisms. Both acupoint laser-irradiation and catgut-embedding ameliorated the OVX-caused metabonomic changes more effectively than hormone replacement therapy (HRT) with nilestriol. Such effects of acupoint stimulations were highlighted in alleviating lipid peroxidation, restoring glucose homeostasis and partial reversion of the OVX-altered amino acid metabolism. These findings provided new insights into the menopause effects on mammalian biochemistry and beneficial effects of acupoint stimulations in comparison with HRT, demonstrating metabonomics as a powerful approach for potential applications in disease prognosis and developments of effective therapies. 



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